Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains
Article Abstract:
A class of binding proteins, called avimers is developed to overcome the limitations of antibodies and other immunoglobulin-based therapeutic proteins. Linking multiple independent binding domains creates avidity and results in improved affinity and specificity compared with conventional single-epitope binding proteins.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
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Ordered surface carbons distinguish antifreeze proteins and their ice-binding regions
Article Abstract:
A generic ice-binding model is formulated and incorporated it into a physicochemical pattern-recognition algorithm. Results show that the algorithm is used to identify a novel antifreeze protein (AFP) from winter rye, and the antifreeze activity of this protein was subsequently confirmed.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
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Isjolation of high-affinity ligand-binding proteins by periplasmic expression with cytometric screening (PECS)
Article Abstract:
Ligand-binding proteins can be isolated from diverse libraries utilizing periplasmic expression with cytometric screening (PECS)
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2001
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