Parameter dependence in continuum electrostatic calculations: a study using protein salt bridges
Article Abstract:
The dependence of stability effect of protein salt-bridges on variations in the atomic parameters and the treatment of the dielectric change at the molecular boundary was investigated using continuum calculations. Results showed that the largest desolvation penalties were produced by approximation of the molecular surface, while smallest was produced by the smoothed boundary. The various parameter sets wee also found to produce relatively similar energetics, which is partly due to compensating effects.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 1998
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A study on local-global cooperativity in protein collapse
Article Abstract:
A study was conducted to analyze the effects of secondary structure formation on the cooperativity of protein collapse. A simple homopolymer framework on a 210 lattice was utilized to carry out the analysis. Results indicated three areas supporting distinct collapse properties. Findings also showed that the collapse transition in the homopolymer chain supports a certain level of cooperativity as observed in the sigmoidal shape of the transition curves.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 1999
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Protein bandwidth in gel electrophoresis: a primary function of migration distance
Article Abstract:
A study was conducted to analyze several factors that may be sources of band broadening in agarose and polyacrylamide gels. These include temperature gradients, Joule heating and electroendosmosis. R-phycoerythrin was the protein utilized in the gel. Gel electrophoresis was performed using a Tris-tricinate buffer. Experimental results indicated that none of the factors could be the cause of band spreading.
Publication Name: Journal of Physical Chemistry B
Subject: Chemicals, plastics and rubber industries
ISSN: 1520-6106
Year: 1998
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