Activation of oxygen nucleophiles in enzyme catalysis
Article Abstract:
The application of certain methods to enzyme reactions for ascertaining how the environment of the enzyme active site affects the reactivity of oxygen nucleophiles, with an emphasis on alcohols is highlighted. Clear evidence is provided by physical chemistry that small increases in electron density on nucleophilic oxygen atoms could result in dramatic rate enhancements for nucleophilic displacements.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
Energetic aspects of cyclic pi-electron delocalization: Evaluation of the methods of estimating aromatic stabilization energies
Article Abstract:
An assessment of cyclic-pi-electron delocalization usually requires comparisons with nonaromatic model compounds or is derived from the nonadditivity of some property based on data for nonaromatic reference. The methods for determining aromatic stabilization energies show the great importance of choosing an appropriate reaction scheme to achieve reliable results.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Tautomeric equilibria in relation to pi-electron delocalization
Article Abstract:
An analysis of the relations between the characteristics of pi-electron delocalization and tautomeric equilibria in selected systems are discussed. Tautomeric equilibria are very important intramolecular proton-transfer reactions, which by definition are associated with changes in pi-electron distribution.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Protein radicals in enzyme catalysis. Mechanism of free radical oxygenation of polyunsaturated fatty acids by cyclooxygenases
- Abstracts: Regioselectivity of the reactions of heteroatom-stabilized allyl anions with electrophiles. The chemistry of vicinal polycarbonyl compounds
- Abstracts: Methods for characterizing zeolite acidity. Physical aspects of photochemistry and radiation chemistry of molecules adsorbed on SiO2, gamma-Al2O3, zeolites, and clays
- Abstracts: Construction of enantiopure pyrrolidine ring system via asymmetric [3+2]-cycloaddition of azomethine ylides. Alkylidenecarbenes, alkylidenecarbenoids, dagger and competing species: which is responsible for vinylic nucleophilic substitution, [1 plus 2] cycloadditions, 1,5-CH insertion and the Fritsch-Buttenberg-wiechell rearrangement?
- Abstracts: Recent developments in isocyanide based multicomponent reactions in applied chemistry. Supramolecular nanotube architectures based on amphiphilic molecules