Applications of sulfoxides to asymmetric synthesis of biologically active compounds
Article Abstract:
Sulfoxides induce the formation of chirals and can be used to prepare biologically active compounds such as carbinols. The substitutes present at the alpha and beta carbon atom determine the structure of the sulfoxide while those on the sulfur atom form a stereogenic center. This stereogenic center controls the stereochemistry of the compounds being formed. The conformation of the compound formed changes in the presence of metal atoms. The formation of optically active secondary methylcarbinols is given.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1995
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Acyclic stereocontrol induced by allylic alkoxy groups. Synthetic applications of stereoselective dihydroxylation in natural product synthesis
Article Abstract:
The allylic alkoxy group can be used to achieve acyclic stereocontrol. These allelic alcohols exhibit stereochemical control during the formation of compounds such as hikizimycin, fungal poisons, diols and iodohydrin. The alcohols are used in the addition of a nitrile oxide to allelic alcohols and ethers and Diels-Alder reactions. Olefines containing one substituent become highly stereoselective on dihydroxylation. However the diastereofacial selectivity of osmylated allylic amino compounds is poor.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1995
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Stereochemical control in organic synthesis using silicon-containing compounds
Article Abstract:
Silicon-containing compounds were employed for organic synthesis stereochemical regulation and stereoselective reaction. Stereochemistry control is achieved by silicon by combining two molecules and stemming transition structure conformation. Chiral information can also be transmitted to organic frameworks by a chiral silyl group. There are various ways of using silyl groups in organic synthesis for stereochemistry regulation.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1997
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- Abstracts: Catalytic asymmetric organozinc additions to carbonyl compounds. Palladium-catalyzed Reppe carbonylation
- Abstracts: Domino reactions in organic synthesis. Stereocontrolled synthesis of tetrasubstituted olefins. Enantioselective palladium-catalyzed transformations
- Abstracts: (pi-allyl)Tricarbonyliron lactone complexes in organic synthesis: a useful and conceptually unusual route to lactones and lactams