Binding energy and catalysis: the implications for transition-state analogs and catalytic antibodies
Article Abstract:
Transition-state analogs are significant for the generation of catalytic antibodies. The transition-state theory and the use of transition-state analogs as enzyme inhibitors and their relevance to catalytic antibodies were investigated. Differential binding affinity was found as the precursor of catalytic behavior but, sets a limit to its magnitude. It was also found that immune response alone cannot build enough binding energy into the antibody combining site.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1997
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Characterization of catalytic surfaces by isotopic-transient kinetics during steady-state reaction
Article Abstract:
Steady-state isotopic-transient kinetic analysis (SSITKA) is an effective technique employed for the investigation of the kinetics of heterogeneous catalytic reactions. SSITKA involves the identification and subsequent measurement of one of the isotopic labels in an effluent species, which are then compared to time of change of the reactant. Experimental considerations, parameter determinants and reactions so far studied using SSITKA are discussed.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1995
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Decontamination of chemical warfare agents
Article Abstract:
Different methods of decontaminating four chemical warfare agents of the vesicating and nerve types were presented. Decontamination processes which included hydrolysis, substitution, oxidation, complexation and enzymatic-mediated interactions were examined. These reactive forms of decontamination offered new effective ways of eliminating hazardous agents from the surface of affected materials.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1992
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