Binuclear metallohydrolases
Article Abstract:
Metallohydrolases with two metal atoms held together by bridging ligands have peptidase or phosphoesterase activity. These include enzymes that catalyze the hydrolysis of the C-N bond of urea and guanidine, the N-terminal peptide bond of proteins and the P-O bond of phosphate monoesters. The peptidase hydrolytic activity involves a nucleophilic attack on the carbonyl carbon, whereas in phosphatases the nucleophilic attack occurs at the phosphorous atom opposite the leaving group. Binuclear metallohydrolases contain a metal-bound solvent nucleophile.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Manganese enzymes with binuclear active sites
Article Abstract:
The binuclear metal centers in enzymes containing manganese share a common bridging ligand derived from a solvent, protein, nucleoside or an amino acid residue. The metal centers exhibit electronic coupling between the metals. The bonds are either covalent or ionic that are formed through ligands or via direct metal-metal forces. The enzymes activate the substrate for oxidation, reduction or deprotonation; ionize water molecules; and stabilize the transition state of the intermediate.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
The catalytic mechanisms of binuclear metallohydrolases
Article Abstract:
Four specific binuclear metallohydrolases, which are experimentally well-developed systems showing the geometric and electronic structures of active sites and transition states for these binuclear metal centers are highlighted. The discussion presented on binuclear metallohydrolases illustrates both mechanistic similarities and functional variations.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2006
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Chemical dynamics at metal surfaces. Reactions of transition metal clusters with small molecules. Structures and dynamics of molecules on liquid beam surfaces
- Abstracts: C-vinylpyrroles as pyrrole building blocks. Quantum mechanical continuum solvation models
- Abstracts: Metalloporphyrins as versatile catalysis for oxidation reactions and oxidativeDNA cleavage. Mechanism of oxidation reactions catalyzed by cytochrome P450 enzymes
- Abstracts: Spillover in heterogeneous catalysis. Modeling the kinetics of Heterogeneous catalysis. Turnover rates in heterogeneous catalysis
- Abstracts: Applications of sulfoxides to asymmetric synthesis of biologically active compounds. Acyclic stereocontrol induced by allylic alkoxy groups. Synthetic applications of stereoselective dihydroxylation in natural product synthesis