Direct cellular responses to platinum-induced DNA damage
Article Abstract:
The article reviews cellular processes that lead to the formation of platinum-DNA adducts and the early events that subsequently transpire. Information on how platinum complexes enter cells are used to discuss the interactions of cellular proteins with platinum-DNA adducts.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2007
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Structure, recognition, and processing of cisplatin-DNA adducts
Article Abstract:
Researchers are still trying to determine exactly how cisplatin destroys cancer cells. The drug binds to DNA and several proteins have been identified that bind to the cisplatin-DNA adduct. These proteins may be involved in the drug's activity against cancer cells.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1999
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Synthetic models for non-heme carboxylate-bridged diiron metalloproteins: strategies and tactics
Article Abstract:
Metalloproteins that are identified to share the carboxylate-bridged diiron active site motif are listed. The activation of dioxygen by diiron (II) compounds that lead to the formation of interesting intermediates is described.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2004
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