Hyaluronan: preparation, structure, properties, and applications
Article Abstract:
The chemical and the physicochemical characteristics of hyaluronan (HA) were reviewed to relate the significance of HA in pharmaceutical research and applications. HA is a linear, unbranched polymer considered as a member of the polysaccharide family having a high molecular weight. The degradation methods for HA were through ultrasonic treatment, pH-dependent and thermal degradation, free radical depolymerization and catalytic enzymes. The physicochemical features of HA made the chemical an important entity in the field of ophthalmology and in drug delivery systems.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1998
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Target-related applications of first principles quantum chemical methods in drug design
Article Abstract:
Applications of quantum mechanics (QM) in drug design are reviewed focusing exclusively on target-based studies carried out on pharmacologically relevant protein systems. It is concluded that QM methods combined with either free energy perturbation or umbrella sampling allow accounting for environmental effects, to accurately estimate the entropy and to calculate a realistic free energy profile associated with a certain biological reaction.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2006
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Gadolinium(III) chelates as MRI contrast agents: structure, dynamics, and applications
Article Abstract:
The structure, physical properties, macromolecular conjugates, and applications of gadolinium are described. Gadolinium is used as a contrast agent in MRI imaging because it has magnetic properties.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 1999
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