Ion channels based on bis-macrocyclic bolaamphiphiles: effects of hydrophobic substitutions

Article Abstract:

Ion channels from bis-macrocyclic bolaamphiphiles have been studied relative to hydrophobic substitution effects. Four new bismacrocyclic bolaamphiphiles were first prepared. In bilayer vesicles the compounds were very much like more hydrophilic derivatives already prepared. Planar bilayer conductance experiments indicated that the new compounds gave rise to a distinctive current-time signal made up of a short rise time, then a longer decay time. Signal shape was found to be cation-dependent, and it was related to moderate cation-cation selectivity. A proposed model for the signal shape has a quick current increase caused by aggregate restructuring and then a longer-lasting decay caused by development of local Donnan potential coming from high cation-anion selectivity.

Ion channels, Cations, Lipid membranes, Bilayer lipid membranes, Anions, Substitution reactions

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The supramolecular architecture of 4-aminoacetophenone (1-(4-fluorophenyl)ethylidene)hydrazone hydrate: double T-contacts and extremely low-density water layers in a mixed azine

Article Abstract:

Crystal structure of unsymmetrical azine 4-aminoacetophenone (1-(4-fluorophenyl)ethylidene)hydrazone hydrate has been determined. Contrary to expectation, there is no inter-water hydrogen bonding in an extremely low-density water layer when 4-aminoacetophenone (1-(4-fluorophenyl)ethylidene)hydrazone hydrate is in the solid state. Water layers connect azine layers though a hydrogen-bonded network. That network has been described through the used of graph set analysis. Comparison of X-ray structures of symmetrical 4-amino- and 4-fluoroacetophenone azines support the existence of the azine bridge as an inhibitor of conjugation.

Usage, Electric properties, Water, Crystallography, Hydrogen bonding, Hydrogen bonds, Aromatic compounds, Layer structure (Solids)

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