Methodologies for generating solution-phase combinatorial libraries
Article Abstract:
Solution-phase combinatorial approach to drug discovery and lead optimization is gaining momentum as an alternative to the solid-phase approach. Great strides in the form of developing methodologies for generating parallel single-compound libraries have been made and automated. Recent developments in the use of chemoenzymatic methods for library generation hold promise to evolving complex libraries for drug discovery.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2000
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Peptide and protein recognition by designed molecules
Article Abstract:
Protein-protein interactions are the essentials of all cellular/organelle normal structure and function and the basis of molecule-based disease therapy. This review focuses on the nature and mechanism of surface recognition of oligopeptides by the complementary, designed molecules with reference to protein-protein interactions.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2000
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Coenzyme A analogues and derivatives: synthesis and applications as mechanistic probes of coenzyme A ester-utilizing enzymes
Article Abstract:
The focus of this review article is the synthesis of coenzyme A (CoA) and unusual derivatives of CoA esters and analogues that can interact with CoA and its ester-utilizing enzymes. Data are also presented on the mechanistic aspects of CoA interaction with analogues as they developed from 1960 to 1980s.
Publication Name: Chemical Reviews
Subject: Chemistry
ISSN: 0009-2665
Year: 2000
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