Computational approaches to discovering semantics in molecular biology
Article Abstract:
Massively parallel computers and special-purpose hardware can be used to perform the computationally demanding task of determining the evolutionary similarities and common structure between sets of DNA nucleotide or protein sequences. The Human Genome Initiative has begun the cataloging of the DNA molecular coding for the estimated 100,000+ genomes and about 3.3 billion nucleotide sequences (bases) spread over the 23 chromosomes. Determination of the nature of individual bases in regards to their evolutionary relationships will be accomplished by three transforming operations: inserting an element into one sequence, deleting an element from a sequence, and replacing an element in a sequence by another. Tools being used to perform these tasks include the Princeton nucleic acid comparator and the massively parallel Connection Machine CM-2.
Publication Name: Proceedings of the IEEE
Subject: Electronics
ISSN: 0018-9219
Year: 1989
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Scientific computing challenges arising from space-borne observations
Article Abstract:
The continuing growth in the use of supercomputers for modeling the vast amounts of physical data generated by space-borne sensors has led to many new insights in both space and earth sciences. These are in such fields as solid earth modeling; global dynamics of the earth surface, atmosphere, and oceans; topographic modeling; dynamics of the sun; the formation of stars; and cosmic background radiation. Work in each field is described at length. The amount and richness of the satellite data and the advances in supercomputer capabilities is driving interdisciplinary scientific computing. Described examples include the interrelationship of biology and chemistry in the oceans, ice-ocean dynamics, development of a core-mantle-lithosphere model, and models of star-galaxy evolution and development.
Publication Name: Proceedings of the IEEE
Subject: Electronics
ISSN: 0018-9219
Year: 1989
User Contributions:
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