Greater influence of central distribution of adipose tissue on incidence of non-insulin-dependent diabetes in women than men
Many studies have established a relationship between obesity and non-insulin-dependent diabetes mellitus (NIDDM). Several of these studies have reported that the incidence of NIDDM is related to the amount of central and/or upper body fat (located in the abdomen and chest area), and two of these studies have suggested that central body fat is more closely associated with NIDDM in women than in men. Therefore, a study was performed to determine the relationship between body fat distribution and NIDDM in men and women. Information on body fat distribution and incidence of NIDDM for 254 men and 366 women (all Mexican-American) was obtained from the San Antonio Heart Study, a study conducted between 1979 and 1982 to determine the incidence of diabetes and heart disease in non-Hispanic whites and Mexican-Americans. For the current study, subjects were followed for eight years to determine how many of them developed NIDDM. Sixteen of the men and 27 of the women developed diabetes. Those who developed diabetes had a higher body mass index (indicative of obesity), greater triceps skinfold thickness (fat measured under the skin of the arm) and a larger proportion of central body fat. The incidence of NIDDM was more strongly associated with central body fat in women than in men. Among women, those with greater amounts of central body fat had a higher risk of developing NIDDM than those with less central body fat. It is concluded that the association between central body fat and the incidence of NIDDM is greater in women than in men. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: American Journal of Clinical Nutrition
Diabetes and hypertension in Mexican American families: relation to cardiovascular risk
Studies on Mexican Americans indicate that a genetic predisposition for hypertension or diabetes can also reveal a susceptibility to cardiovascular disease. Using a likelihood-based variance component approach, researchers found significant correlations between diabetes and hypertension family histories and incidence of cardiovascular disease. These findings can help physicians assess Mexican Americans who may be at risk before actual manifestation of the disease.
Publication Name: American Journal of Epidemiology
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