Cardiovascular risks of antiretroviral therapies

Article Abstract:

The use of highly active antiretroviral therapy (HAART) has led to sustained reductions in mortality from HIV infection, but it is also associated with metabolic complications that might increase patients' cardiovascular disease risk. It is revealed that considerable progress is made in the development of newer antiretroviral therapies that have a better metabolic profile relating to dyslipidemia, hyperglycemia, and lipodystrophy.

Health aspects, Cardiovascular diseases, Prevention, Risk factors, HIV infection, HIV infections, Highly active antiretroviral therapy, Clinical report

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Angiogenesis in ischemic and neoplastic disorders

Article Abstract:

This article presents a critical review of clinical evaluations of novel therapeutic approaches for stimulating angiogenesis in ischemic tissue and its inhibition in cancerous tissue. Angiogenesis is triggered by the hypoxia-inducible factor 1 mediated production of vascular endothelial growth factor involved in the advent of angiogenesis.

Physiological aspects, Drug therapy, Hypoxia, Anoxia, Neovascularization, Vascular endothelial growth factor, Angiogenesis inhibitors

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Current concepts in thrombotic thrombocytopenic purpura

Article Abstract:

A study is conducted to review the characteristics and function of a circulating zinc metalloprotease, ADAMTS13, whose deficiency causes thrombotic thrombocytopenic purpura (TTP). Results show that the identification of ADAMTS13 raises the possibility of providing molecular therapy for the treatment of TTP.

Care and treatment, Diagnosis, Causes of, Thrombocytopenic purpura, Disease/Disorder overview

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