Cytomegalovirus infection in women attending a sexually transmitted disease clinic
Cytomegalovirus (CMV) has been isolated from cervical secretions and semen, suggesting that sexual contact may play an important role in its transmission. Further evidence in support of this hypothesis is based on the observation that CMV is more common in sexually active women than in celibate women. However, CMV can also be transmitted by nonsexual routes, since CMV infection can occur prior to sexual contact. To better characterize the relationship between sexual practices and CMV infection, 1,481 women (1,101 white, 301 black, 79 other) attending the Seattle-King County Department of Public Health Sexually Transmitted Disease Clinic, May 1980 to September 1985, were interviewed and screened for CMV. The mean age of the study group was 23.6 years, and the average number of different sex partners was 10. The prevalence of CMV infection was higher among black women (78 percent) than white women (59 percent). CMV infection in white women was associated with an increased number of sexual partners, younger sexual debut and recent new sexual partners. CMV infection was inversely related to the use of condoms. In black women, CMV was associated with greater numbers of recent sex partners, new sex partners and cervical infection with Chlamydia trachomatis. It is concluded that CMV infection is related to sexual practices, independent of demographic variables. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: Journal of Infectious Diseases
Phase I study of high-dose, intravenous rsCD4 in subjects with advanced HIV-1 infection
High dosages of intravenous recombinant soluble CD4 may be administered safely up to 10 weeks and can produce antiviral results in patients with advanced HIV-1 infection. Three patients with advanced HIV infection were given daily infusions of rsCD4 at 10 mg kg for four weeks to block replication, then 5 mg kg for 4 weeks and 1 mg kg for two weeks to constrain the virus. All three patients studied showed reduction in plasma viremia, gained weight and reported feeling healthier at conclusion of the study. The HIV isolate of one subject was somewhat resistant to rsCD4 in vivo, but clinical benefits were gained. Dosages two to three times daily may have a long-term effect on HIV replication.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Clinical and epidemiologic features of primary HIV infection
Many physicians may miss the diagnosis of HIV infection, especially in people who do not engage in risky sexual behavior. Of 46 patients who contracted HIV infection, 41 had symptoms so severe they sought medical attention. Some were even hospitalized. Yet only 25% were accurately diagnosed. Almost half had only one sexual partner in the months before infection. Misdiagnosis occurs because HIV infection initially causes symptoms that are similar to other diseases. Oral-genital contact may be a substantial risk factor for acquiring HIV.
Publication Name: Annals of Internal Medicine
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