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Detection of HIV vaccine-induced cell-mediated immunity in HIV-seronegative clinical trial participants using an optimized and validated enzyme-linked immunospot assay

Article Abstract:

The interferon-[gamma] (IFN[gamma]) enzyme-linked immunospot (ELISPOT) assay is used to detect a broad range of HIV-specific ELISPOT responses to peptide pools of overlapping 22mers, 15mers, or 9mers in study volunteers receiving DNA- or adenovirus vector-based HIV vaccines and in HIV-seropositive donors. The results have shown that the validated ELISPOT assay using 15mer peptide pools and the positivity criteria is a sensitive and specific assay for the detection of HIV vaccine-induced cell-mediated immunity.

Author: Collins, Kelly B., Tobery, Timothy W., Shiver, John W., Gupta, Swati B., Mogg, Robin, Anderson, Kiersten, Casimiro, Danilo R., Dubey, Sheri, Clair, James, Tong-Ming Fu, Liming Guan, Long, Romnie, Gaunt, Christine, Fernandez, V. Rose, Lan Zhu, Kierstead, Lisa, Thaler, Scott, Straus, Walter, Mehrotra, Devan
Publisher: Lippincott Williams & Wilkins, WK Health
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2007
Evaluation

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Detection of HIV vaccine-induced cell-mediated immunity in HIV-seronegative clinical trial participants using an optimized and validated enzyme-linked immunospot assay

Article Abstract:

The interferon-[gamma] (IFN[gamma]) enzyme-linked immunospot (ELISPOT) assay is used to detect a broad range of HIV-specific ELISPOT responses to peptide pools of overlapping 22mers, 15mers, or 9mers in study volunteers receiving DNA- or adenovirus vector-based HIV vaccines and in HIV-seropositive donors. The results have shown that the validated ELISPOT assay using 15mer peptide pools and the positivity criteria is a sensitive and specific assay for the detection of HIV vaccine-induced cell-mediated immunity.

Author: Collins, Kelly B., Tobery, Timothy W., Shiver, John W., Gupta, Swati B., Mogg, Robin, Anderson, Kiersten, Casimiro, Danilo R., Dubey, Sheri, Clair, James, Tong-Ming Fu, Liming Guan, Long, Romnie, Gaunt, Christine, Fernandez, V. Rose, Lan Zhu, Kierstead, Lisa, Thaler, Scott, Straus, Walter, Mehrotra, Devan
Publisher: Lippincott Williams & Wilkins, WK Health
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2007
Patient outcomes

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Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon

Article Abstract:

Anti-HIV-1 T-cell immune responses among 363 unvaccinated adults infected with diverse HIV-1 clades is compared. It is revealed that the response rates to clade B Gag and/or clade B Nef in Botswana, with 95 percent and Cameroon, with 98 percent are similar.

Author: Schechter, Mauro, Coplan, Paul M., Straus, Walter L., Shiver, John W., Wolfe, Nathan D., Gupta, Swati B., Pitisuttithum, Punee, Burke, Donald, Mast, Christopher T., Vardas, Eftyhia, Freed, Dan, Mbewe, Bernard, Mogg, Robin, Novitsky, Vlad, Dubey, Sheri, A., Kallas, Esper G., Condra, Jon H., Long, Ronnie S., Anderson, Kiersten, Casimiro, Danilo R.
Publisher: Lippincott Williams & Wilkins, WK Health
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2006
Cameroon, Botswana, Health aspects, Prognosis, HIV infection, HIV infections, HIV patients, T cells

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Subjects list: Usage, Measurement, AIDS vaccines, Immune response, Immunoenzyme technique, Immunoenzyme techniques, Clinical report, Research
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