Discordant immunologic and virologic responses to highly active antiretroviral therapy are associated with increased mortality and poor adherence to therapy

Article Abstract:

The independent association of discordant virologic and immunologic responses to highly active antiretroviral therapy (HAART) with mortality is examined. The results show that the discordant responses are independently associated with an increased risk of mortality and are, in turn, associated with poor adherence to therapy.

Mortality, Patient outcomes, Highly active antiretroviral therapy

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Why are baseline HIV RNA levels 100,000 copies/mL or greater associated with mortality after the initiation of antiretroviral therapy?

Article Abstract:

The study evaluated whether baseline CD4 cell count and plasma HIV RNA predicted virologic suppression are rebound among adherent HIV-infected patients. Baseline HIV RNA (less than or equal to 100,000) copies/mL was associated with a significantly lower likelihood of ever achieving HIV RNA suppression during follow-up.

HIV patients, Antiviral agents, Antiretroviral agents

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Gender differences in HIV-1 RNA rebound attributed to incomplete antiretroviral adherence among HIV-infected patients in a population-based cohort

Article Abstract:

A study to evaluate whether gender differences existed in time to HIV-1 RNA rebound among those patients who experienced HIV-1 RNA suppression was done. It was found that higher rates of HIV-1 RNA rebound among women were primarily explained by incomplete adherence that was more prevalent among women in the cohort.

Care and treatment, HIV infection, HIV infections, Sex differences (Biology)

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