Effect of ACAT inhibition on the progression of coronary artherosclerosis
Article Abstract:
The enzyme acyl-coenzyme A:cholesterol acyltransferase (ACAT) Inhibitors was found to have antiatherosclerotic effects on some animal models. When ACAT inhibitor pactimibe was tested on 408 patients with coronary disease, it was found that ACAT inhibitor did not improve the primary efficacy variable (percent atheroma volume) and adversely affected two major secondary efficacy measures assessed by intravascular untrasonography.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
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Nitroprusside in critically ill patients with left ventricular dysfunction and aortic stenosis
Article Abstract:
The drug nitroprusside may improve heart function in patients with severe aortic stenosis and heart failure while they wait for an aortic valve replacement, according to a study of 25 patients. Aortic stenosis occurs when the aortic valve in the heart becomes stiff and no longer functions properly. Nitroprusside belongs to a group of drugs called vasodilators because they dilate blood vessels.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003
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Statin therapy, LDL cholesterol, C-reactive protein and coronary artery disease
Article Abstract:
The reduced rate of progression of atherosclerosis associated with intensive Statin treatment is significantly related to greater reductions in the levels of both atherogenic lipoproteins and C-reactive protein (CRP). Statins have a wide range of biologic effects in addition to lipid lowering, including reducations in the levels of CRP.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
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- Abstracts: Effect of calcium supplementation on bone loss in postmenopausal women. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis
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