Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose

Article Abstract:

A retrospective study of European-American patients was conducted to determine the effect of vitamin K epoxide reductase complex 1 (VKORC1) haplotypes on the warfarin dose. The result showed that VKORC1 haplotypes can be used to stratify patients into low-, intermediate and high dose warfarin groups and may explain differences in dose requirements among the patients of different ancestries.

Author: Gage, Brian F., Eby, Charles S., Blough, David K., Nickerson, Deborah A., Rieder, Mark J., Reiner, Alexander P., Rettie, Allan E., Thummel, Kenneth E., McLeod, Howard L.
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2005
United Kingdom, Drug therapy, Dosage and administration, Genetic disorders, Warfarin, Haplotypes

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Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events

Article Abstract:

A prospective, population-based study assesses whether polymorphisms in the C-reactive protein (CRP) gene are associated with circulating plasma CRP, carotid intima-media thickness (CIMT) and cardiovascular disease (CVD) events. Results suggest that genetic variation in the CRP gene is associated with plasma CRP levels and CVD risk in older adults.

Author: Kuller, Lewis H., Tracy, Russell P., Psaty, Bruce M., Cushman, Mary, Hindorff, Lucia A., Carlson, Christopher S., Nickerson, Deborah A., Walston, Jeremy, Reiner, Alexander P., Lange, Ethan M., Lange, Leslie A., Durda, J. Peter, Bis, Joshua C., Donglin Zeng; Danyu Lin
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2006
C-reactive protein, Genetic polymorphisms, Clinical report

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Cardiovascular mortality risk in chronic kidney disease: Comparison of traditional and novel risk factors

Article Abstract:

The comparison of traditional and novel risk factors as predictors of cardiovascular mortality is discussed. Results revealed that traditional cardiovascular risk factors had larger associations with cardiovascular mortality than novel risk factors in elderly persons with chronic kidney disease.

Author: Shlipak, Michael G., Cushman, Mary, Newman, Anne, Manolio, Teri A., Psaty, Bruce, Fried, Linda F., Stehman-Breen, Catherine, Siscovick, David, Peterson, Do, Bleyer, Anthony
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2005
United States, Health aspects, Evaluation, Patient outcomes, Risk factors (Health), Aged patients, Elderly patients, Kidney diseases

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Subjects list: Research, Cardiovascular diseases, Risk factors
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