Effect of guanethidine on the natural history of post-traumatic algodystrophy
Treatment with guanethidine may decrease finger tenderness in patients with algodystrophy. Algodystrophy is a combination of pain, swelling and stiffness that affects the hands or feet after an injury. Among 20 patients who developed algodystrophy after an arm fracture, 10 were treated with a series of intravenous guanethidine blockades and 10 were treated with physical therapy alone (control group). Treatment with guanethidine caused a short-term improvement in finger tenderness, finger stiffness, swelling and grip strength. Five and six months after the start of treatment, patients in the guanethidine group had less pain in their fingers than those in the control group.
Publication Name: Annals of the Rheumatic Diseases
Natural adjuvants: endogenous activators of dendritic cells
Dendritic cells can be activated by necrotic cells, virally infected cells, and stressed cells but not healthy cells or apoptotic cells. These endogenous activators could be used as natural adjuvants to stimulate the immune system.
Publication Name: Nature Medicine
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