Anagrelide for essential thrombocythemia
The FDA has approved anagrelide hydrochloride for treatment of essential thrombocythemia. This is a disorder which causes too many platelets in the blood, a situation which can lead to blood clots and spontaneous bleeding. The drug, marketed by Roberts as Agrylin, is taken orally and has fewer side effects than existing treatments for this disorder. Patients do not seem to develop resistance to the drug which must be taken indefinitely. Side effects include headache and diarrhea. There are reports of heart failure and heart attack, although cardiovascular effects are generally mild.
Publication Name: Medical Letter on Drugs and Therapeutics
Heterologous antisera and antivenins are essential biologicals: perspectives on a worldwide crisis
Many developing countries face many problems acquiring adequate and affordable supplies of traditional vaccines or their alternatives. These alternative products include monoclonal antibodies or purified antibodies from the blood of immune humans or horses. Obstacles to effective immunization in developing countries include prohibitive production costs, inconsistent supply, wars, poor quality control, and objections from animal rights activists. Unpurified versions of vaccinations produced by many developing countries, if they are produced at all, often result in adverse reactions.
Publication Name: Annals of Internal Medicine
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