HIV-1-specific CD4 helper function in persons with chronic HIV-1 infection on antiviral drug therapy as measured by ELISPOT after treatment with an inactivated, gp120-depleted HIV-1 in incomplete Freund's adjuvant
Article Abstract:
The HIV-1 immunogen Remune appears to activate T cells that produce interferon gamma, according to a study of 10 HIV patients. This constitutes the first AIDS treatment that may actually restore the immune system.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2000
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Early clinical markers and CD4 percentage in subjects with human immunodeficiency virus infection
Article Abstract:
There appears to be a relationship between early opportunistic infections in HIV patients and a drop in the percentage of CD4 cells. This was demonstrated in 103 HIV-infected patients who were receiving immunotherapy with an inactivated form of HIV. A drop in the percentage of CD4 cells occurred sooner and more rapidly in the patients who developed an early opportunistic infection such as oral Candida infection or oral hairy leukoplakia. Patients with the greatest decline had 5 times the risk of these infections.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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Effect of immunization with an inactivated gp120-depleted HIV-1 immunogen on beta-chemokine and cytokine production in subjects with HIV-1 infection
Article Abstract:
Immunization with the HIV-1 immunogen REMUNE appears to induce T cell proliferation and the production of cytokines that can inhibit HIV. Researchers studied the production of a cytokine called RANTES and interferon-gamma production in blood samples from 15 HIV-infected patients who had been immunized with REMUNE. REMUNE stimulated interferon-gamma production and RANTES production. Immunization also seemed to control viral reproduction and stabilize CD4 T cell counts.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
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