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Lack of interferon response in animals to naked siRNAs

Article Abstract:

A demonstration that it is possible to administer naked, synthetic siRNAs to mice and downregulate an endogenous exogenous target without inducing an interferon response is presented. Co-injection of siRNA and a luciferase-expressing plasmid into mice followed by in vivo whole body imaging confirms the uptake and sequence-specific function of injected synthetic siRNA.

RNA interference, Luciferase

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Is it a DC, is it an NK? No, it's an IKDC

Article Abstract:

Interferon-producing killer dendritic cell (IKDC) is a new type of immune system cell in mice. IKDCs are able to kill cells lacking self major histocompatibility complex (MHC) molecules, secrete large amounts of interferon, process antigens and present them to T lymphocytes.

Physiological aspects, Immune system, Killer cells

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Sensing the danger in RNA

Article Abstract:

The potential dangers of using short interference RNA (siRNA)-mediated interference in a therapeutic setting are discussed. The technique is found to induce the type I interferon pathway (IFN-I), a primary cellular defense mechanisms against pathogens in human immune cells.

RNA, Immune response, Dendritic cells

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