Vasoactive mediator release by fetal endothelial cells in intrauterine growth restriction and preeclampsia

Article Abstract:

During preeclampsia the fetus produces more cyclic guanosine monophosphate (GMP) to dilate blood vessels and allow blood to flow freely. Preeclampsia is a serious complication of pregnancy. During growth restriction the fetus does not produce cyclic GMP, which could cause blood vessels to constrict.

Physiological aspects, Preeclampsia

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Increased nuchal translucency with normal karyotype

Article Abstract:

The association between increased fetal nuchal translucency (NT) thickness in chromosomally normal fetuses and a wide range of fetal malformations, deformations, dysgeneses, and genetic syndromes is reviewed. The vast majority of fetal abnormalities associated with increased nuchal translucency can be diagnosed by a series of investigations that can be completed by 14 weeks of gestation.

United States, Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Gynecological R&D, Diagnosis, Medical examination, Fetal development, Gynecological research

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Maternal serum concentration of soluble fms-like tyrosine kinase 1 and vascular endothelial growth factor in women with abnormal uterine artery Doppler and in those with fetal growth restriction

Article Abstract:

A study is conducted to determine whether maternal serum concentration of the angiogenic factor vascular endothelial growth factor (VEGF) and its circulating antagonist, soluble fms-like tyrosine kinase 1 (sFlt-1) are altered in pregnancies that subsequently develop preeclampsia (PE) and in those with established fetal growth restriction (FGR). It is found that maternal serum concentration of sFlt-1 in pregnancies with FGR is increased but is not evident in pregnancies with impaired placentation that subsequently developed either FGR or PE.

Health aspects, Analysis, Risk factors, Pregnancy, Complications of, Pregnancy complications, Tyrosine

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