Non-HDL cholesterol, apolipoproteins A-I and B100, standard lipid measures, lipid ratios, and CRP as risk factors for cardiovascular disease in women

Article Abstract:

The clinical utility of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density cholesterol (HDL-C), non-HDL-C, apolipoproteins A-I and B100, high sensitivity CRP, and the ratios of total cholesterol to HDL-C, LDL-C were compared to HDL-C, apolipoprotein B100 to apolipoprotein A-I, and apolipoprotein B100 to HDL-C. The non-HDL-C and the ratio of total cholesterol to HDL-C were better than apolipoprotein fractions in the prediction of future cardiovascular events in women.

United States, Product information, Testing, C-reactive protein

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Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: The Reynolds Risk Score

Article Abstract:

The development and validation of cardiovascular risk algorithms for women based on a large panel of traditional and novel risk factors is presented. The accuracy of two clinical algorithms is demonstrated for global cardiovascular risk prediction that has reclassified 40% to 50% of women at intermediate risk into higher- and lower-risk categories.

Care and treatment, Disease/Disorder overview

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Pharmacogenetic study of statin therapy and cholesterol reduction

Article Abstract:

The ways in which genetic variation influences response to pravastatin therapy is described. It concluded that individual heterozygous for a genetic variant in the HMG-CoA reductase gene may experience significantly smaller reductions in cholesterol when treated with pravastatin.

Science & research, Research, Genetic aspects, Cholesterol, Pravastatin, Genetic variation

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