Meningitis caused by human herpesvirus-6

Article Abstract:

Since the discovery of the human herpesvirus-6 (HHV-6) in 1986, several diseases have been reported to be associated with HHV-6 infection. These diseases include roseola infantum (fever and red rash in infants), mononucleosis, hepatitis, lymphadenitis (inflammation of the lymph nodes), atypical polyclonal lymphoproliferative disorder (abnormal growth of lymph tissue), and hemophagocytic syndrome (destruction of red blood cells). This article describes the case reports two infants with roseola infantum, meningitis (inflammation of the brain and spinal cord membranes), and HHV-6 infection. Both infants had symptoms of fever and cough for three days followed by the appearance of a red rash with pimples. In one case the rash appeared on the face, scalp, and neck, and in the other case it appeared on the trunk and lower extremities. One of the infants had four seizures. Blood cultures were negative for Epstein-Barr virus, cytomegalovirus, and Toxoplasma gondii. No viral pathogens were identified in samples of cerebral spinal fluid. Blood samples taken on days 15 and 17 of illness were found to contain antibodies to HHV-6 (indicating an infection with HHV-6). Both patients made full recoveries. Previous studies have shown that HHV-6 can infect cells in the nervous system, and may have the potential to cause nervous system disease. Infants with unexplained inflammatory diseases of the nervous system should be tested for HHV-6 infection. (Consumer Summary produced by Reliance Medical Information, Inc.)

Causes of, Meningitis

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High costs stall drive for infant hepatitis B immunizations

Article Abstract:

Physicians are finding it too expensive to comply with recommendations from the Centers for Disease Control, the American Academy of Pediatrics and the American Medical Association to vaccinate all infants against hepatitis B. The estimated cost of the infant series was approximately $30, but physicians are discovering that the actual cost is as much as $160. Part of the expense is due to waste; one vaccine comes in multi-dose vials that must be used immediately or discarded.

Economic aspects, Prices and rates, Prevention, Children, Hepatitis B, Immunization of children, Immunization, Hepatitis B vaccine, Hepatitis B vaccines

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