Plasma glutathione S-transferase Alpha 1-1: a more sensitive marker for hepatocellular damage than serum alanine aminotransferase in hypertensive disorders of pregnancy

Article Abstract:

Measuring blood levels of glutathione S-transferase Alpha 1-1 (GSTA1-1) may allow physicians to diagnose many serious complications of pregnancy sooner. This enzyme is released into the bloodstream during liver damage. Two pregnancy complications that involve liver damage are preeclampsia and the HELLP syndrome. Researchers measured blood levels of GSTA1-1 and another liver enzyme called alanine aminotransferase in 274 pregnant women. GSTA1-1 levels were substantially higher than alanine aminotransferase levels in the women with preeclampsia or HELLP syndrome.

Diagnosis, Measurement, Hypertension in pregnancy, Gestational hypertension, Glutathione transferase

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N-acetyl-transferase phenotype and risk for preeclampsia

Article Abstract:

A study is undertaken to determine whether the N-acetyltransferase (NAT) phenotype contributes to the susceptibility for the development of preeclampsia. The fast NAT acetylator status, which may result in altered NAT detoxification capacity, is associated with preeclampsia.

United States, Genetic aspects, Transferases

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Marginal maternal vitamin B12 status increases the risk of offspring with spina bifida

Article Abstract:

The association of B vitamins and homocysteine as potential risk factors for offspring with spina bifida is examined. The risk of an offspring with spina bifida is increased by 3.5 fold due to the maternal serum vitamin B12 concentration of <=185 pmol/L.

Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Gynecological R&D, B-Complex Vitamin Preps, Causes of, Influence, Homocysteine, Spina bifida, Vitamin B, Vitamin B complex, Gynecological research

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