Plasma glutathione S-transferase Alpha 1-1: a more sensitive marker for hepatocellular damage than serum alanine aminotransferase in hypertensive disorders of pregnancy
Article Abstract:
Measuring blood levels of glutathione S-transferase Alpha 1-1 (GSTA1-1) may allow physicians to diagnose many serious complications of pregnancy sooner. This enzyme is released into the bloodstream during liver damage. Two pregnancy complications that involve liver damage are preeclampsia and the HELLP syndrome. Researchers measured blood levels of GSTA1-1 and another liver enzyme called alanine aminotransferase in 274 pregnant women. GSTA1-1 levels were substantially higher than alanine aminotransferase levels in the women with preeclampsia or HELLP syndrome.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1998
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N-acetyl-transferase phenotype and risk for preeclampsia
Article Abstract:
A study is undertaken to determine whether the N-acetyltransferase (NAT) phenotype contributes to the susceptibility for the development of preeclampsia. The fast NAT acetylator status, which may result in altered NAT detoxification capacity, is associated with preeclampsia.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2005
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Marginal maternal vitamin B12 status increases the risk of offspring with spina bifida
Article Abstract:
The association of B vitamins and homocysteine as potential risk factors for offspring with spina bifida is examined. The risk of an offspring with spina bifida is increased by 3.5 fold due to the maternal serum vitamin B12 concentration of <=185 pmol/L.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2004
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