Reduction of circulating annexin A5 levels and resistance to annexin A5 anticoagulant activity in women with recurrent spontaneous pregnancy losses
Article Abstract:
A study is carried out to investigate whether levels of annexin A5, evidence for resistance to annexin A5 activity and levels anti-annexin A5 antibodies might be altered in women with a history of recurrent spontaneous pregnancy losses. It is found that reduction of annexin A5 and interference with its anticoagulant and biding activities are associated significantly with a history of recurrent spontaneous pregnancy losses and these data support the concept of a significant role for annexin A5 in the maintenance of pregnancy.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2006
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Antiphospholipid immunoglobulin G antibodies reduce annexin-V levels on syncytiotrophoblast apical membranes and in culture media of placental villi
Article Abstract:
Immunoglobulin G (IgG) in patients with the antiphospholipid syndrome appears to inhibit the activity of a powerful anti-blood-clotting protein called annexin V. This could account for the increased incidence of miscarriage among pregnant women with this syndrome. Annexin V levels were lower in placental tissue from a patient with the antiphospholipid syndrome than in a healthy mother. Annexin V production decreased in normal placental tissue treated with IgG from patients with the antiphospholipid syndrome.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
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Analysis of circulating annexin A5 parameters during pregnancy: Absence of differences between women with recurrent spontaneous pregnancy losses and controls
Article Abstract:
An investigation on whether levels of annexin A5(AnxA5)-related parameters, including plasma levels of AnxA5, AnxA5 anticoagulant activity and AnxA5 binding activity, and anti-AnxA5 antibodies are altered in pregnant women with a history of recurrent spontaneous pregnancy losses (RSPL). No significant differences were observed during pregnancy in women with RSPL and controls, with the state of pregnancy itself associated with altered levels of AnxA5 parameters.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2006
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