Relations among CD4 Lymphocyte Count Nadir, Antiretroviral Therapy, and HIV-I Disease Progression: Results from the EuroSIDA Study
HIV patients with a low CD4 white blood cell count progress more rapidly to AIDS, even if their CD4 count eventually rises. Researchers studied HIV patients to determine the relationships between changing CD4 levels and the progression of HIV infection to AIDS or death. Patients with CD4 levels of 50 cells/cubic mm or lower progressed much more rapidly than those with a count of 200 or higher. Patients with CD4 levels which rose to 200 from a lower level survived longer, but continued to progress more rapidly to AIDS than those who maintained a higher CD4 count.
Publication Name: Annals of Internal Medicine
AIDS- Related Opportunistic Illnesses Occurring After Initiation of Potent Antiretroviral Therapy: The Swiss HIV Cohort Study
Highly active antiretroviral therapy (HAART) can reduce the risk of opportunistic infections in HIV patients but does not completely prevent them. In a study of 2,410 HIV patients who were taking HAART, 143 developed an opportunistic infection after they started HAART. However, the rate of new opportunistic infections dropped 50% three months later, and over 80% six or more months later. Those with CD4 T cell counts below 200 were more likely to develop an opportunistic infection than those with counts above 200.
Publication Name: JAMA, The Journal of the American Medical Association
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