Risk of Down syndrome and any clinically significant chromosome defect in pregnancies with abnormal triple-screen and normal targeted ultrasonographic results
Article Abstract:
Ultrasound imaging shows promise in helping identify which women should have amniocentesis to diagnose a chromosomally abnormal fetus. Over 1,000 women with an abnormal triple screen had an ultrasound fetal evaluation. The triple screen is a blood test that shows that the fetus has an increased risk of having Down syndrome or other genetic defects, but follow-up amniocentesis will reveal that most fetuses are normal. Abnormal ultrasound results increased the odds of Down syndrome 50-fold and other defects by 19-fold. Normal ultrasound results decreased the odds of Down syndrome from 1 in 270 to 1 in 2,100.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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New Down syndrome screening algorithm: ultrasonographic biometry and multiple serum markers combined with maternal age
Article Abstract:
A screening method for Down syndrome that includes fetal measurements appears to be more accurate than the triple-screen method. The triple-screen method measures blood levels of various hormones and proteins. In a study of 1,743 pregnant women, researchers measured the length of the fetal upper arm and combined that with maternal age and measurements of human chorionic gonadotropin and alpha fetoprotein in the mother's blood. This technique was more accurate in identifying fetuses with Down syndrome than the triple-screen method. Amniocentesis confirmed the diagnosis in 31 fetuses.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1998
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Middle cerebral artery Doppler velocimetric deceleration angle as a predictor of fetal anemia in Rh-alloimmunized fetuses without hydrops
Article Abstract:
Decreased blood flow in the middle cerebral artery of a fetus can identify fetuses with anemia caused by an Rh-mismatch. This is determined by measuring the deceleration angle in the artery using Doppler velocimetry.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 2000
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