Suppressing the self in rheumatoid arthritis

Article Abstract:

Rheumatoid arthritis cause chronic inflammation of peripheral joints, cartilage destruction and bone erosion in about 1 percent of human population and its treatment though slows down the disease progression but has serious side effects. A mouse with collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis was studied by injecting it with monoclonal antibodies to CD137 (4-1 BB), a T-cell costimulatory receptor.

Author: Mittler, Robert S.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
Inflammation, T cells

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA

VIP: a very important protein in arthritis

Article Abstract:

Research presented finds that inflammatory arthritis can be suppressed by the introduction of the vasoactive intestinal peptide (VIP). Topics include the pathogenesis of rheumatoid arthritis, the anti-inflammatory effects of VIP, and how the protein can regulate innate and adaptive immune responses to arthritis.

Author: Firestein, Gary S.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2001
Analysis, Immunological research, Immunologic research, Antiarthritic agents, Vasoactive intestinal peptides

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA

Evolving concepts of rheumatoid arthritis

Article Abstract:

Rheumatoid arthritis (RA) is symmetric polyarticular arthritis and is a major cause of disability. Specific therapeutic interventions can be designed based on the pathogenic mechanism to suppress synovial inflammation and joint destruction in rheumatoid arthritis.

Author: Firestein, Gary S.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
Synovial fluid

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Subjects list: Research, United States, Rheumatoid arthritis
This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.