The class I and class II proteins of the human major histocompatibility complex
Research on the structure of class I and class II proteins of the human major histocompatibility complex (MHC) has provided a basic understanding of these structures that could greatly expand the understanding of immunological diseases at the cellular level. Both proteins are made up of two membrane proximal immunoglobulin-like domains. These domains form a superdomain made up of eight beta strands, forming a platform. Two upward-bowing alpha helixes are found on top of this platform. The cleft between the helixes and the floor of the beta strands is lined with polymorphic amino acids. This is the place where peptides are bound for presentation to the immune system. Understanding the ways in which these peptides are presented to the immune system may provide novel approaches to molecular-level treatments of immunological disorders. Class II MHC proteins are implicated in autoimmune diseases where peptide bonding areas to the MHC have been ascertained for multiple sclerosis and pemphigus vulgarus, a serious skin disease.
Publication Name: JAMA, The Journal of the American Medical Association
Proper use of beryllium-containing alloys
Dentists should avoid using metal alloys that contain beryllium if possible and should follow all Occupational Safety & Health Administration (OSHA) recommendations for reducing exposure to beryllium if they must use them. Beryllium is used in the metal parts of crowns, bridges, and dentures but it is a hazardous substance and possibly carcinogenic. Grinding and polishing the alloy is especially hazardous.
Publication Name: Journal of the American Dental Association
Heterogeneous enantioselective hydrogenation over cinchona alkaloid modified platinum: Mechanistic insights into a complex reaction
The modification of a metal surface by a strongly adsorbed chiral organic molecule has proven to be interesting strategy for heterogeneous chiral catalysis. The way in which enantiodifferentiation can be induced on a catalytically active surface is presented and the models proposed for the platinum-cinchona system in the light of the existing molecular knowledge is validated.
Publication Name: The New England Journal of Medicine
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