Metabolic polymorphisms affecting activation of toxic and mutagenic arylamines
Article Abstract:
Extensive research on the biotransformation of aromatic amines and their polymorphism during acetylation processes revealed the detrimental effects caused by these compounds in human colorectal cancer. The carcinogenic properties of the heterocyclic amines were caused by the sulfation and acetylation reactions that occurred within the body forming N-acetoxy metabolites which could undergo further transformations increasing the development of colon or bladder cancer. These metabolic reactions also led to inherent acetyltransferase polymorphism which contributed to the harm derived from heterocyclic amines.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Cloning of the H1 histamine receptor
Article Abstract:
A study of the H1 histamine receptor using molecular cloning of bovine adrenal medulla showed the differences between H1 and H2 histamine receptors. Although the homology of the two receptors are highly similar, the intracellular loop of the H1 receptor is longer, suggesting its function in phosphoinositide metabolism. The H1 receptors also have threonine and asparagine residues, respectively, and are also found in H1 receptors instead of threonine and aspartate, which are typical in H2 receptors.
Publication Name: Trends in Pharmacological Sciences
Subject: Pharmaceuticals and cosmetics industries
ISSN: 0165-6147
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Human adrenoreceptor polymorphisms: evolving recognition of clinical importance. Schwartz and Rosenkilde reply
- Abstracts: Muscarinic receptor-mediated stimulation of adenylyl cyclase. H3 receptor gene is cloned at last
- Abstracts: Nerve membrane Na+ channels as targets of insecticides. The role of excitotoxicity in organophosphorous nerve agents central poisoning