Hydrogen/deuterium exchange mass spectrometry - A window into amyloid structure
Article Abstract:
The hydrogen-deuterium exchange mass spectrometry (HX-MS) technique, used to understand the secondary structure of the protein, which rearrange to give the H-bonding relationship within the aggregate structure is described giving a clear picture of the protein misfolding events leading to formation of fibrils. A detailed investigation of the monomers structures, protofibrils and fibrils, the structural relationships among these states, the energetic input of H-bonding to fibril stability, and the plasticity of the H-bond network is discussed.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2006
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The chemistry of life's origin: A carbonaceous meteorite perspective
Article Abstract:
Carbonaceous chondrite meteorites are primitive asteroidal fragments that contain organic carbon offering a glimpse of the abiotic chemical processes that preceded the onset of life. The organic material in them displays structures as diverse as kerogen-like macromolecules and simpler soluble compounds that range from polar amino acids and polyols to nonpolar hydrocarbons.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2006
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The characterization of protein post-translational modifications by mass spectrometry
Article Abstract:
Spectrometric and proteomic approaches are used to identify and characterize covalent modification in post-translational modifications of protein during various biological processes.
Publication Name: Accounts of Chemical Research
Subject: Science and technology
ISSN: 0001-4842
Year: 2003
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