Author's response to commentary on "Revisiting the role of fat mass in the life extension induced by caloric restriction."
Article Abstract:
It was previously hypothesized that fat mass has an important role to play in human longevity. The hypothesis does not contradict new discoveries showing the genetic basis for longevity. In fact, the first hypothesis provides an insight into the interaction between genes and the environment and how the modulation of gene expression may result in longevity. The relationship between genes and caloric restriction may be explained further by new discoveries in fat-derived peptides.
Publication Name: The Journals of Gerontology, Series A
Subject: Seniors
ISSN: 1079-5006
Year: 1999
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Commentary: nuclear receptors and myosin heavy chain gene expression in the aged myocardium
Article Abstract:
Long et al's (1999) paper on the physiology of aging rats contributes to the extant body of knowledge by being the first to examine the mechanisms underlying transitions in myosin heavy chain gene expression resulting from the aging process. Their results showing altered mRNA and protein abundance for retinoid X receptor gamma and thyroid hormone receptor beta 1 indicate that nuclear receptors may have a role in myosin heavy chain gene transitions with aging.
Publication Name: The Journals of Gerontology, Series A
Subject: Seniors
ISSN: 1079-5006
Year: 1999
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A coordinate upregulation of antioxidant gene activities is associated with the delayed onset of senescence in a long-lived strain of Drosophila
Article Abstract:
It is shown that the delayed onset of senescence is the cause of the extended longevity phenotype (ELP) of the long-lived strain of Drosophila. However, a particular larval environment is necessary for the genetically competent animals to develop the resistance to exogenous paraquat characteristic of the ELP. In these animals, induction causes a series of coordinated increases in their antioxidant defense system mRNA levels.
Publication Name: The Journals of Gerontology, Series A
Subject: Seniors
ISSN: 1079-5006
Year: 1995
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