Commentary on "Application of Exogenously Regulatable Promoter Systems to Transgenic Models for the Study of Aging."
Article Abstract:
Morgan et al's (1999) paper on the use of transgenic animals in gerontologic research examines the problems associated with this approach and discusses some solutions. They rightly articulate the issue in terms of gene expression at the appropriate time and place. The authors also examine the strengths and limitations of three expression systems, namely, tetracycline, RU486 and ecdysone inducible systems. The study's implications for further research are discussed.
Publication Name: The Journals of Gerontology, Series A
Subject: Seniors
ISSN: 1079-5006
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Cell cycle progression, aging, and cell death
Article Abstract:
The workshop on Cell Cycle Progression, Aging and Cell Death, held on Oct 6, 1993, in Bethesda, MD, helped analyze the developments in these disciplines. The workshop was sponsored by the Division of Research Grants of the National Institutes of Health. More than 150 registrants participated in discussions on molecular cytological research, genetic factors, cellular immortalization and other factors related to aging.
Publication Name: The Journals of Gerontology, Series A
Subject: Seniors
ISSN: 1079-5006
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
No evidence for a general change in contractile responsiveness of the mesenteric artery with aging
Article Abstract:
Experimental studies indicate that variations in calcium concentration or aging do not influence the contractile response of the human mesenteric artery to physiological vasoconstrictors. The reduction of extracellular ionized calcium does not inhibit contraction to U46619, a thromboxane analogue, while the contraction to noradrenaline is only slightly affected.
Publication Name: The Journals of Gerontology, Series A
Subject: Seniors
ISSN: 1079-5006
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Development and validation of a geriatric knowledge test for medical students. The effects of Megestrol Acetate suspension for elderly patients with reduced appetite after hospitalization: A phase II randomized clinical trial
- Abstracts: Relationship of obesity and physical fitness to cardiopulmonary and metabolic function in healthy older men. Hypocholesterolemia as a predictor of death: a prospective study of 224 nursing home residents
- Abstracts: Hierarchical linear modeling analyses of the NEO-PI-R scales in the Baltimore Longitudinal Study of Aging. The effect of social comparison information on the life satisfaction of frail older persons
- Abstracts: Loneliness is a unique predictor of age-related differences in systolic blood pressure
- Abstracts: Relationship of events and affect in the daily life of an elderly population. Age differences in conversational source monitoring