Post-translational control
Article Abstract:
There are various changes in post-translational control in senescent cells which include modifications in proteolysis, phosphorylation and dephosphorylation modifications. Changes in proteolysis processing affects the rate of protein production. Others implicatethe decline of protein degradation pathways with age. Moreover, specific phosphorylation and dephosphorylation processes affecting cell cycle regulationmay also be involved in senescence.
Publication Name: Journals of Gerontology
Subject: Seniors
ISSN: 0022-1422
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Regulatory pathways and differentiation
Article Abstract:
Different cell types exhibit different alterations in cellular functions during senescence and terminal differentiation. Human melanocytes show growth arrest during senescence and terminal differentiation but increase in melanin is only found in the terminal diferentiation. Endothelial cells, on the other hand, do not undergo terminal differentiation but arrest in G0 phase of the cell cycle occurs.
Publication Name: Journals of Gerontology
Subject: Seniors
ISSN: 0022-1422
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Nursing home characteristics and potentially preventable hospitalizations of long-stay residents. Admission and continued-stay criteria for assisted living facilities
- Abstracts: Extent and determinants of hospitalization in a cohort of older disabled people. Diabetes mellitus in older adults: underdiagnosis and undertreatment
- Abstracts: Health and social antecedents of relocation in rural elderly persons. Cohort analysis of retirement preparation, 1974-1981
- Abstracts: Health and social antecedents of relocation in rural elderly persons. part 2 Nonsteroidal anti-inflammatory drugs and blood pressure in elderly population
- Abstracts: Cardiovascular response during postural change in the elderly. Postural sway characteristics of the elderly under normal and altered visual and support surface conditions