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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer

Article Abstract:

The identification of a somatic mutation in human breast, colorectal and ovarian cancers that has resulted in a glutamic acid to lysine substitution at amino acid 17 (E17K) in the lipid-binding pocket of v-akt murine thymoma viral oncogene homologue 1 (AKT1) kinase is reported. The mutation has shown a direct role of AKT1 in human cancer and the E17K substitution has decreased the sensitivity to an allosteric kinase inhibitor.

Author: Bittner, Michael, Moses, Tracy Y., Robbins, Christiane M., Carpten, John D., Patel, Ketan, Faber, Andrew L., Horn, Candice, Donoho, Gregory P., Briggs, Stephen L., Hostetter, Galen, Boguslawski, Sophie, Savage, Stephanie, Uhlik, Mark, Aimin Lin, Jian Du, Yue-Wei Qian, Zeckner, Douglas J., Tucker-Kellogg, Greg, Touchman, Jeffrey, Mousses, Spyro, Schevitz, Richard, Mei-Huei T. Lai, Blanchard, Kerry L., Thomas, James E.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Colorectal cancer, Ovarian cancer, Oncogenes

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Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome

Article Abstract:

Research demonstrates that mutations in lamin A cause the Hutchinson-Gilford progeria syndrome leading to premature aging. Results show that the syndrome gene is resides in chromosome 1q and lamin A sequence indicates that 18 out of 20 cases of the disorder harbour an identical de novo single-base substitution within exon 11. Furthermore, fibroblasts cells show abnormalities of the nuclear membrane.

Author: Collins, Francis, Singer, Joel, Glover, Thomas W., Boehnke, Michael, Eriksson, Maria, Brown, W. Ted, Gordon, Leslie B., Glynn, Michael W., Scott, Laura, Erdos, Michael R., Robbins, Christiane, M., Moses, Tracy Y., Berglund, Peter, Dutra, Amalia, Pak, Evgenia, Durkin, Sandra, Csoka, Antonei B.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Influence, Nuclear membranes, Nuclear membrane, Fibroblasts, Progeria, Structure

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The cause for a US prospective cohort study of genes and environment

Article Abstract:

A change in the environment, in combination d with genetic disposition, has produced most recent epidemics of chronic disease. Replication of associations and estimation of their magnitude, consistency and temporality are best obtained through prospective population-based cohort studies.

Author: Collins, Francis
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
Cohort analysis, Genetic research, Human chromosomes

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Subjects list: Research, United States, Gene mutations, Gene mutation, Genetic aspects
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