Amyloid ox-tox transducers
Article Abstract:
The receptor for advanced glycation end products (RAGE) and the scavenger receptor (SR) regulate the stimulation of microglia in individuals with Alzheimer's Disease by amyloid-beta-peptide. The RAGE and SR direct the deposition of microglia at the sites of amyloid-beta-peptide deposition. Microglia play a major role in the inflammatory processes associated with amyloid plaques. The RAGE and the SR are potential targets of drugs that are designed to decrease neuronal injury, inflammation and vascular damage of brain occuring during Alzheimer's Disease.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1996
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Human haemoglobin from transgenic tobacco
Article Abstract:
Functional recombinant human hemoglobin has been obtained from transgenic tobacco plants. Coding sequences of the alpha- and beta-globins of the human hemoglobin HbA were fused to the sequence of the chloroplastic transit peptide of the small subunit of Rubisco from Pisum sativum L. Following co-expression with the binary plasmid pBIOC59, tobacco plants were transformed using Agrobacterium tumefaciens strains. Recombinant hemoglobin purified from the seed extracts showed similar biphasic recombination kinetics to those of HbA.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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Myoglobin-like aerotaxis transducers in Archaea and Bacteria
Article Abstract:
Haemoglobin and myoglobin are haem-containing proteins and are required in oxygen transport and storage. Studies of globins from Bacteria and Eukarya indicate a common ancestor. A new class of haem-containing proteins serving as sensors have been revealed, and now the first myoglobin-like, haem-containing protein has been found in the Archaea.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
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