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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus

Article Abstract:

A mechanism the controlling thymic transcription of a prototypic tissue-restricted human auto-antigen gene, CHRNA1 is described. Findings revealed a critical function of autoimmune regulator (AIRE) and the interferon signalling pathway in regulating quantitative expression of this auto-antigen in the thymus.

Author: Gajdos, Philippe, Kyewski, Bruno, Vincent, Angela, Garchon, Henri-Jean, Xiayi Ke, Giraud, Matthieu, Taubert, Richard, Vandiedonck, Claire, Levi-Strauss, Matthieu, Pagani, Franco, Baralle, Francisco E., Eymard, Bruno, Tranchant, Christine, Willcox, Nick, Beeson, David
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Autoimmunity, Acetylcholine, Acetylcholine receptors

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Structural basis of West Nile virus neutralization by a therapeutic antibody

Article Abstract:

West Nile virus is a mosquito-borne flavivirus closely related to the human epidemic-causing dengue, yellow fever and Japanese encephalitis virus. The mechanism of neutralization by the E16 monoclonal antibody that specifically binds receptor-binding domain III (DIII) is investigated.

Author: Diamond, Michael S., Oliphant, Theodore, Nybakken, Grant E., Johnson, Syd, Fremont, Daved H., Burke, Stephen
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
Drug therapy, Monoclonal antibodies, West Nile virus, Neutralization (Chemistry)

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Herpesvirus latency confers symbiotic protection from bacterial infection

Article Abstract:

Herpesvirus latency persists for the life of the host and it is shown to confer a surprising benefit to the host. Herpesvirus latency might sculpt the immune response to self and environment antigens through establishment of a polarized cytokine environment.

Author: Miller, Virginia L., Barton, Erik S., White, Douglas W., Diamond, Michael S., Engle, Michael, Cathelyn, Jason S., Brett-McClellan, Kelly A., Virgin, Herbert W., IV
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Human immunogenetics, Herpesvirus diseases, Herpesvirus infections, Herpes, Report

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Subjects list: Research, Interferon
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