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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Artemisinins target the SERCA of Plasmodium falciparum

Article Abstract:

Research points out that artemisinins inhibit the SERCA orthologue PfATP6 of Plasmodium falciparum in oocytes of Xenopus and that chelation of iron by desferrioxamine abolishes the antiparasitic activity of artemisinins resulting in the weakening of the inhibition of PfATP6. Together, the data suggest that artemisinins act by inhibiting PfATP6 following iron activation.

Author: Kimura, M., Webb, R.J., Ward, S.A., Eckstein-Ludwig, U., van Goethem, I.D.A., East, J.M., Lee, A.G., O'Neill, P.M., Bray, P.G., Krishna, S.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
United Kingdom, Japan, Antimalarial & Antifungal Preps, Physiological aspects, Adenosine triphosphatase, Antimalarials, Mechanical chemistry, Mechanochemistry, ATPases

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Analyse this

Article Abstract:

In industry, it is essential for monitoring the safety of drugs and, in basic science, it is necessary for drawing casual relationships conclusively, for instance, between multiple genes and a single disease. Today, biostatistics offer lucrative salaries and a variety of projects that go beyond simple 'number crunching'.

Author: Powell, Kendall
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
General services, Safety and security measures, Biometry, Biometric technology, Genes

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Escape from inhibition

Article Abstract:

Mutations in the Abl protein have been the cause of some leukaemias. The determination of its structure and the identification of Abl variants resistant to an anti-leukaemia drug reveal regions of the protein needed for its regulation.

Author: Courtneidge, Sara A.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Care and treatment, Analysis, Leukemia, Protein research

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Subjects list: Research, Drugs
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