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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Beta-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression

Article Abstract:

Many beta-lactam antibiotics that are potent stimulators of GLT1 expression are discovered by using a blinded screen of 1,040 FDA-approved drugs and nutritionals. Beta-Lactams and various semi-synthetic derivatives are potent antibiotics that act to inhibit bacterial synthetic pathways.

Author: Bergles, Dwight E., Rothstein, Jeffrey D., Lin Jin, Fisher, Paul B., Gupta, Pankaj, Patel, Sarjubhai, Shuy Vang Toan, Regan, Melissa R., Hoberg, Margaret Dykes, Haenggeli, Christine, Vidensky, Svetlana, Yanhua H. Huang, Chung, Dorothy S., Zao-zhong Su
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
United States, Science & research, Microbiological synthesis, Beta lactam antibiotics

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Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18

Article Abstract:

Research is presented concerning the high-affinity NA+-dependent L-glutamate/D, L-aspartate cell-membrane transport protein excitatory amino-acid carrier 1. The characterization of an EAAC1-associated protein GTRAP3-18 is discussed.

Author: Rothstein, Jeffrey D., Chien-Iiang Glenn Lin, Orlov, Irina, Ruggiero, Alicia M., Dykes-Hoberg, Margaret, Lee, Andy, Jackson, Mandy
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
Cell membranes

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Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins

Article Abstract:

Research is presented concerning the use of a two-hybrid screen of yeast to determine the interaction of proteins, GTRAP41 and GTRAP48, which are involved in the regulation of the glutamate transporter EAAT4.

Author: Rothstein, Jeffrey D., Dykes-Hoberg, Margaret, Jackson, Mandy, Wei Song, Mu-Ya Liu, Lin Jin, Chien-Iiang G.Lin, Bowers, William J., Federoff, Howard J., Sternweis, Paul C.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
Neurotransmitters

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Subjects list: Research, Glutamate, Physiological aspects, Proteins, Letter to the Editor
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