Boa constrictor or rattlesnake?
Article Abstract:
Dynamin, a relatively large protein made up of four subunits, may, like all other known GTPases, act as a switch to regulate endocytosis. It appears that GDP-dynamin is recruited to the forming bud, where it forms into rings. The protein's intrinsic GTPase activating protein is activated on completion of a spiral around the neck of the bud, when dynamin tetramers from one end of the spiral stack onto tetramers at the other end. This research has left a number of unanswered questions, including why dynamin changes shape on binding GTP.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
Identification of a specific Ins(1,3,4,5)P4-binding protein as a member of the GAP1 family
Article Abstract:
A protein receptor for inositol 1,3,4,5-tetrakisphosphate, Ins(1,3,4,5)P4, has been purified from stimulated cell tissue that specifically binds Ins(1,4,5)P3. The protein shows a specificity for Ins(1,3,4,5)P4's isomeric configuration and has a high affinity for it. The behavior the protein and its in vitro GAP activity against Ras and Rap indicate a GTPase-activating protein of the GAP1 family while Ras GAP activity is stimulated by Ins(1,3,4,5)P4 and inhibited by phospholipids.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
Ringing necks with dynamin
Article Abstract:
The nature of functioning of Dynamin a large GTPase, essential for endocytosis of surface membranes, is discovered by Jemy E. Hinshaw and Kohye Takei. Their study reveals that Dynamic spontaneously self-assembles itself into rings of coated veside buds. This spontaneous self-assembly enables the Dynamin to interact with membrane vesides and remove them from plasma membrane.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1995
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: NIDCD research on taste and smell. A specific amyloid-beta protein assembly in the brain impairs memory. Aluminum - Alzheimer's link?
- Abstracts: Not picture-perfect. Identification of cells initiating human melanomas
- Abstracts: Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Failure of B-cell differentiation in mice lacking the transcription factor EBF
- Abstracts: Bed site characteristics of pronghorn fawns. Whole genome amplification for sequencing and applications in conservation genetics
- Abstracts: Conspecific sperm precedence in Drosophila. Selfish genes: a green beard in the red fire ant. All's fair when love is war