Cyclic ADP-ribose as an endogenous regulator of the non-skeletal type ryanodine receptor Ca2+ channel
Article Abstract:
The cyclic adenosine 5'-diphosphoribose (cADPR) found in many mammalian tissues stimulates the cardiac but the skeletal isoform of the ryanodine receptor Ca2+ channel (RyRc) is not activated by it. An endogenous activation of the non-skeletal type of RyRc is cADPR, and in Ca2+ signalling, its role may be similar to inositol 1, 4, 5-triphosphate.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1993
User Contributions:
Comment about this article or add new information about this topic:
Solace for the broken-hearted?
Article Abstract:
The heart was thought to lack the capacity to regenerate after injury. But the identification of progenitor cells in the heart that can divide and mature into heart muscle suggests that the heart has some regenerative capacity after all.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells
Article Abstract:
L-type Ca2+ channels (LCCs) and the coupling with ryanodine receptors are discussed.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2001
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Developmental and activity-dependent regulation of kainate receptors at thalamocortical synapses. Identification of genes that modify ataxin-1-induced neurodegeneration
- Abstracts: Superoxide dismutase as a target for the selective killing of cancer cells. A radical approach to treatment
- Abstracts: Single amino-acid changes in HIV envelope affect viral tropism and receptor binding. G alpha i and G alpha o are target proteins of reactive oxygen species
- Abstracts: Tyrosine kinase activation through the extracellular domains of cytokine receptors. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling
- Abstracts: Smectic ordering in solutions and films of a rod-like polymer owing to monodispersity of chain length. Autonomic healing of polymer composites