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Zoology and wildlife conservation

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Developmental and activity-dependent regulation of kainate receptors at thalamocortical synapses

Article Abstract:

Fast excitatory synaptic transmission in the mammalian brain is mostly mediated by ionotrophic glutamate receptors. The three subtypes of these receptors are AMPA, NMDA and kainate. Kainate-receptor subunits are expressed widely in the mammalian central nervous system. The developing thalamocortical synapses are shown to express postsynaptic kainate receptors along with AMPA receptors, although the two subtypes do not co-localize. The kainate receptor contribution to transmission falls during the period for experience-dependent plasticity.

Author: Isaac, John T.R., Kidd, Fleur L.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
Observations, Brain research, Neural transmission, Synaptic transmission

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Identification of genes that modify ataxin-1-induced neurodegeneration

Article Abstract:

Research on genetic aspects of neurodegeneration liked to ataxin-1, is examined in detail.

Author: Fernandez-Funez, Pedro, Nino-Rosales, Maria Laura et al
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Analysis, Neurobiology, Genetic research

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