Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

Article Abstract:

The Vav protein encoded by the proto-oncogene vav, is a signalling molecule required for the proliferation of B and T cells controlled by the antigen receptors. Mice chimeras containing RAG-2(super-/-) and no vav gene contain less thymocytes and T cells in the spleen and lymph nodes than the wild-type mice. CD4+8- and CD4-8+ T cells are present in these mutants. The number of B cells in these chimeras is the same as the wild-type but B-1 cells are absent. The T and B cells of the mutants with a null vav gene are hyporeactive in response to antigen receptor stimulation.

Physiological aspects, Genetic aspects, T cells, Proto-oncogenes, Mice as laboratory animals, House mouse

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Replication protein A interacts with AID to promote deamination of somatic hypermutation targets

Article Abstract:

The mechanism of AID targeting to in-vitro-transcribed substrates harboring somatic hypermutations (SHM) motif is characterized and it is shown that the replication protein A (RPA), a ssDNA-binding protein involved in replication, recombination and repair were responsible for the targeting activity of activation-induced cytidine deaminase (AID). It is concluded that the aspects of B-cell specificity of SHM can be explained by the biochemical functions of the AID-RPA interaction.

United States, DNA-ligand interactions, DNA binding

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Transcription-targeted DNA deamination by the AID antibody diversification enzyme

Article Abstract:

Study of the enzymactic activity of AID (activation-induced cytidine demanase) in lymphocytes is explored. The article provides supporting data in the form of charts and graphs.

Immunological research, Immunologic research, Enzymatic analysis

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