Female development in mammals is regulated by Wnt-4 signalling
Article Abstract:
Male gonadal differentiation is triggered by the Y-chromosome-encoded testis-determining factor (SRY), leading to differentiation of Sertoli cell precursors and the secretion of Mullerian inhibiting substances (MIS), a hormone, inducing regression of the Mullerian duct. It is reported that Wnt-4 is required for development of the female and suppression of the male reproductive system. It is proposed that Wnt-4 regulates Mullerian duct formation, controls gonadal steroidogenesis and perhaps supports oocyte development.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Melanin-concentrating hormone is the cognate ligand for the orphan G-protein-coupled receptor SLC-1
Article Abstract:
There is evidence suggesting that the neuropeptide melanin-concentrating hormone (MCH) is an important component of neuropeptide systems involved in food intake and energy balance regulation. The 353-amino-acid human orphan G-protein coupled receptor SLC-1 expressed in HEK293 cells is found to bind MCH with sub-nanomolar affinity. The SLC-1 messenger RNA and protein is also found to be expressed in the ventormedial and dorsomedial nuclei of the hypothalamus.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1999
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Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta
Article Abstract:
The orphan nuclear receptor ERR-beta is not activated by oestrogens, and its expression during embryogenesis defines a subset of extra-embryonic ectoderm, later forming the chorion dome. This suggests that ERR-beta is involved in early placental development. It was found that homozygous mutant embryos generated by targeted disruption of the Estrrb gene suffered sever placental formation impairment and showed abnormal chorion development.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
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