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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Identification of a tumour suppressor network opposing nuclear Akt function

Article Abstract:

A demonstration that the (PML) tumour suppressor prevents cancer by inactivating phosphorylated AKT inside the nucleus and that Pml deficiency on its own leads to tumorigenesis in the prostate is presented. Results reveal that Pml orchestrates a nuclear tumour suppressor network for inactivation of nuclear pAkt, and thus highlight the importance of AKT compartmentalization in human cancer pathogenesis and treatment.

Author: Pandolfi, Pier Paolo, Cordon-Cardo, Carlos, Scaglioni, Pier Paolo, Trotman, Lloyd C., Alimonti, Andrea, Koutcher, Jason A.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
Cancer

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Identification of a tumour suppressor network opposing nuclear Akt function

Article Abstract:

A demonstration that the (PML) tumour suppressor prevents cancer by inactivating phosphorylated AKT inside the nucleus and that Pml deficiency on its own leads to tumorigenesis in the prostate is presented. Results reveal that Pml orchestrates a nuclear tumour suppressor network for inactivation of nuclear pAkt, and thus highlight the importance of AKT compartmentalization in human cancer pathogenesis and treatment.

Author: Pandolfi, Pier Paolo, Cordon-Cardo, Carlos, Scaglioni, Pier Paolo, Trotman, Lloyd C., Alimonti, Andrea, Koutcher, Jason A.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2006
United States, Analysis, Prostate cancer, Phosphorylation

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Taking apart a cancer protein

Article Abstract:

Evidences are provided to reveal the necessity of fusion protein for acute promyelocytes leukemia (APL). In APL cancerous cells harbour a chromosome translocation that fuses the promyelocytic leukemia (PML) gene to the gene for retinoic acid receptor-alpha (RAR alpha), giving rise to fusion proteins, PML-RARalpha and RARalpha-PML.

Author: Scaglioni, Pier Paolo, Pandolfi, Pier Pandolfi
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2003
Research and Development in the Physical, Engineering, and Life Sciences, Research and Testing Services, Cancer & Cell R&D, Cancer research, Cancer genetics, Oncology, Experimental

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Subjects list: Research, Prevention, Tumor suppressor genes, Tumour suppressor genes
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