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Zoology and wildlife conservation

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Abstracts » Zoology and wildlife conservation

Interferon-gamma elicitis arteriosclerosis in the absence of leukocytes

Article Abstract:

Arterial endothelial expression of major histocompatibility complex (MHC) class I and II antigens is not constitutive. It is sustained by exogenous immunomodulatory cytokine interferon-gamma (IFN-gamma) and disappears in vivo in the absence of species-specific factors. It appears that the pattern and degree of MHC antigen expression in vascular grafts from cytokine-treated animals is physiological. It was established that IFN-gamma acts on transplanted segments of artery to prompt arteriosclerotic changes in the absence of detectable leukocytes by potentiating platelet-derived growth factor-induced mitogenesis.

Author: Tellides, George, Tereb, Denis A., Kirkiles-Smith, Nancy C., Kim, Richard W., Wilson, Jean H., Schechner, Jeffrey S., Lorber, Marc I., Pober, Jordan S.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Physiological aspects, Arteriosclerosis

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A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

Article Abstract:

Chronic activation of both human and murine CD4+ T cells in the presence of interleukin (IL)-10 produces CD4+ T-cell clones. These have low proliferative capacity and produce low levels of IL-2, high levels of IL-10 and no IL-4. The antigen-specific T-cell clones inhibit colitis induced in SCID mice by pathogenic CD4+CD45RBhigh splenic T cells. Tr1 cells suppress immune responses directed against other antigens in the microenvironment, and they could therefore possibly be used to control T-cell-mediated disease, even when the identity of the pathogenic antigen has not been established.

Author: Antonenko, Svetlana, O'Garra, Anne, de Vries, Jan E., Groux, Herve, Bigler, Mike, Rouleau, Matthieu, Roncarolo, Maria Grazia
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 1997
Prevention, Colitis, T cell proliferation

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Commit ye helpers

Article Abstract:

T-bet, a new TH1-specific factor has been isolated. It controls interferon-gamma expression and represses TH2-specific cytokines.

Author: O'Garra, Anne
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Observations, Immunological research, Immunologic research

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Subjects list: Research, Interferon gamma
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