Ligand-receptor binding revealed by the TNF family member TALL-1

Article Abstract:

The tumour necrosis factor (TNF) ligand TALL-1 and its cognate receptors, BCMA, TACI and BAFF-R were identified as members of the tumour necrosis factor superfamily, which are essential factors contributing to B-cell maturation. It was revealed that one disulphide bridge in BAFF-R is critical for determining the binding specificity of the extracellular domain eBAFF-R to TALL-1 instead of APRIL, a closely related ligand of TALL-1, which was confirmed by binding experiments in vitro.

Ligand binding (Biochemistry), Tumor necrosis factor, Tumour necrosis factor

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Structure of the replicative helicase of the oncoprotein SV40 large tumor antigen

Article Abstract:

Research describes the X-ray structure of the hexameric large tumor antigen oncoprotein exhibiting DNA helicase activity. The hexamer protein binds both single- and double-stranded DNA. It is organized into two tiers which can rotate and produce an 'iris' effect and distort or melt, at the replication fork, the origin and unwinding DNA.

United States, China, Analysis, Physiological aspects, Polyoma virus, Polyomavirus, Structure-activity relationships (Biochemistry), DNA binding proteins, Tumor antigens, Structure, Tumour antigens, DNA replication

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Structural snapshots along the reaction pathway of ferredoxin-thioredoxin reductase

Article Abstract:

The exploration of structures of ferredoxin-thioredoxin reductase (FTR) provides a structural framework for understanding the mechanism of disulphide reduction by an iron-sulphur enzyme and unknown interaction networks of both ferredoxin (Fdx) and Trx (thioredoxins).

Thioredoxin, Ferredoxins

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