Abstracts - faqs.org

Abstracts

Zoology and wildlife conservation

Search abstracts:
Abstracts » Zoology and wildlife conservation

Mapping the conformational wave of acetylcholine receptor channel gating

Article Abstract:

It has been possible to make a linear free-energy relationships (LFER) analysis of the gating reaction pathway of the muscle acetylcholine receptor. This research obtained a snapshot of a number of regions of the receptor at the transition state in terms of their approximate positions along the reaction coordinate. The fact that mutational effects can be ordered in an LFER is strong evidence that the mutations in question do not change the structure of the protein in extremely complicated ways. The systematic investigation of such mutant series can thus be seen as a very good analytical tool for looking in detail at allosteric-transition pathways.

Author: Grosman, Claudio, Zhou, Ming, Auerbach, Anthony
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2000
Allosteric proteins

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


A stepwise mechanism for acetylcholine receptor channel gating

Article Abstract:

Single-molecule kinetic analysis is used to detect the transition state of gating conformational change and estimate relative timing of M2 motions in the [alpha]-subunit of the murine acetylcholine receptor. Results show that core of the channel serves both as a gate that regulates ion flow and as a hub that directs the propagation of gating isomerization through membrane domain of the acetylcholine receptor.

Author: Auerbach, Anthony, Purohit, Prasad, Mitra, Ananya
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2007
Carrier proteins, Transport proteins

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Reaction mechanism determines NMDA receptor response to repetitive stimulation

Article Abstract:

The kinetics of transmitter binding and channel gating in single-channel currents from recombinant NR1/NR2A receptors are examined to show, that the synaptic response to trains of impulses is determined by the molecular reaction mechanism of the receptor. The molecular machinery of neurotransmitter receptors also determines the shape of the postsynaptic response to a single stimulus.

Author: Auerbach, Anthony, Popescu, Gabriela, Robert, Antoine, Howe, James R.
Publisher: Macmillan Publishing Ltd.
Publication Name: Nature
Subject: Zoology and wildlife conservation
ISSN: 0028-0836
Year: 2004
Analysis, Chemical reaction, Rate of, Chemical kinetics, Neurotransmitter receptors

User Contributions:

Comment about this article or add new information about this topic:

CAPTCHA


Subjects list: Research, Acetylcholine, Acetylcholine receptors
Similar abstracts:
  • Abstracts: Searching for FLASH domains. Inhibition of death receptor signals by cellular FLIP. Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
  • Abstracts: Off the rails: Aviation's role in climate change is causing a storm. Murder by medicine
  • Abstracts: Linnaeus in the information age. The legacy of Linnaeus. The love of plants
  • Abstracts: Landscape and edge effects on the distribution of mammalian predators in Missouri
  • Abstracts: Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron
This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.
Some parts © 2023 Advameg, Inc.